Abstract
There are considered results of studies on the association between parental age at conception and risk of various childhood and adult-onset cancers in progeny. In spite of inconsistency of data available it is possible to affirm that advanced parental age is a risk factor of cancer in progeny as well as of other adverse health effects. Paternal age seems to be more significant then maternal age due to particularity of gametogenesis in men lasted during whole life (as opposed to women). In a result sperm accumulates much more potential carcenogenic injuries (mutations, epigenetic alterations, particularity of telomeres) transmitted to progeny. The standard designs of studies are described (case-control, population cohort) as well as sources of personal information (Cancer Registers, Registers of Births, interview), parameters of assessment of parental age effect (mean age of parents in case and control groups, odds ratio - OR, relative risk - RR). The causes of discrepancy of results are discussed. Some unusual results are described (association between parental age and hematological cancer, in adult offspring limited to participants without siblings in childhood, protective effect of older ages of parents for some kinds of malignancies in children) which need further investigations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
