Abstract

Objective: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobiological disorder for which effective and safe medication is recommended as first-line treatment. However, many parents and teachers do not believe that ADHD is a disorder or do not accept medication treatment in China. Treatment is often short term or intermittent. Our study aimed to investigate the clinical effect of employing a 4-week, session-based training for both parents and teachers in improving medication adherence for primary school children with ADHD.Methods: From January 2018 to December 2018, a total of 5,118 primary school children were screened. Among 211 children diagnosed with ADHD, 116 were assigned to the intervention group and 95 to the control group. This study provided systematic training for parents and teachers in the intervention group. The training consisted of education about the disorder and ADHD behavioral intervention for both parents and teachers as well as classroom management techniques for just the teachers. A cluster randomized controlled trial (RCT) was conducted to investigate the effect of this training at 6 months follow-up. The study determined medication adherence using a questionnaire and scoring with a rating scale at baseline and at the 6 month follow-up endpoint. The questionnaire was self-report.Results: The study population had a relatively low rate of attention deficit hyperactivity disorder (4.1%) compared to the generally accepted prevalence. After the training, more parents and teachers believed that ADHD is a neurobiological disorder and that medication is the first line treatment. At 6 months follow-up, the Medication Adherence Report Scale (MARS) score for the intervention group was 22.8 ± 0.75 and 16.5 ± 1.63 for the control group (t = 5.217, P < 0.01). Based on parents' reports and medical records, 82 children (70.69%) were continuously taking medication for 6 months in the intervention group, while only 35 children (36.84%) were doing so in the control group. In the intervention group, the mean SNAP-IV score was 1.98 ± 0.42 at baseline but 0.99 ± 0.31 at 6-month follow-up. In the control group, the mean SNAP-IV score was 1.89 ± 0.47 at baseline but 1.37 ± 0.42 at 6-months follow-up (F = 2.67, P = 0.009). Factors influencing medication adherence for children with ADHD were parent's beliefs, teacher's beliefs, socioeconomic status, adverse effect, insurance coverage, gender, and trust of the medical system.Conclusions: Our findings indicate that comprehensive training programs improve the understanding of ADHD and medication adherence for both children's parents and teachers, providing a promising approach for improving clinical efficacy for children with ADHD.

Highlights

  • Attention-deficit/hyperactivity disorder (ADHD) is a common neurobiological disorder, characterized by symptoms of overactivity, impulsivity, and inattention [1]

  • This study was a cluster randomized controlled trial (RCT) to investigate the effect of parent and teacher training at 6 months follow-up. It consisted of three parts: ADHD screening and diagnosis, parent and teacher training, and evaluation of the effect of the training

  • 230 (68.66%) were physician- diagnosed with ADHD

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Summary

Introduction

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobiological disorder, characterized by symptoms of overactivity, impulsivity, and inattention [1]. Effective and safe medication is recommended as the first-line treatment for ADHD [3]. Primary medications in China include methylphenidate (MPH) and atomoxetine (ATX). Stimulants such as MPH increase dopamine in the brain generally, while ATX leads to a selective increase in norepinephrine and an indirect increase of dopamine in the frontal cortex [4]. Medication adherence is important because untreated ADHD can result in serious consequences with lifelong effects, such as school difficulties, fewer friends, arrests, unwanted pregnancy, and alcohol or drug abuse [5]. It has been reported that medication treatment for children with ADHD can reduce the risk of criminality, comorbid psychiatric disorders, and substance abuse in adolescence and adulthood [6, 7]. High adherence to ADHD medication has been reported to result in higher academic achievement among children with ADHD [8, 9]

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