Abstract

Rates of implantation of prosthetic valves and cardiac devices have increased significantly in the last thirty years, accounting, at least in-part, for the growing incidence of infective endocarditis cases. Prosthetic valve endocarditis (PVE) is an endovascular, microbial infection occurring on parts of a valve prosthesis or on reconstructed native heart valves. We present a case of a 63-year-old man with multiple comorbidities including extensive cardiovascular disease, who recently underwent bioprosthetic aortic valve replacement. Patient presented to the emergency department with exertional chest pain, dyspnea, fever, melena and lethargy. Blood cultures grew Streptococcus salivarius and transesophageal echocardiography confirmed PVE with an aortic paravalvular abscess. The patient was treated with appropriate antimicrobial therapy based on culture sensitivity and subsequently referred to cardiothoracic surgery for urgent evaluation. This case highlights several important points which include but are not limited to: investigation into the pathogen Streptococcus salivarius and its relationship to other known pathogens, understanding of the complications associated with PVE, and the importance of early identification of PVE and initiation of medical and surgical therapy with respect to prognosis.

Highlights

  • Infective endocarditis (IE) is a rare infectious disease with an annual incidence ranging from 3 to 7 per 100,000 person-years according to recent population surveys

  • We present a case of prosthetic valve endocarditis (PVE) in a patient who underwent bioprosthetic aortic valve replacement (AVR)

  • Workup of a possible gastrointestinal bleed was deferred in favor of management of Prosthetic valve endocarditis (PVE), his gastrointestinal symptoms may be connected to S. salivarius as this bacterium was shown to have a connection to streptococcus bovis, a gram positive bacteria well known to be associated with endocarditis and malignant gastrointestinal disease

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Summary

Introduction

Infective endocarditis (IE) is a rare infectious disease with an annual incidence ranging from 3 to 7 per 100,000 person-years according to recent population surveys. Prosthetic valves and cardiac devices are well established risk factors for IE. Rates of implantation of these devices have increased significantly in the last thirty years, accounting for the growing rates of infectious endocarditis cases. In a recent cohort of 2,781 adults in 25 countries with an established diagnosis of IE, one-fifth had a prosthetic valve and 7% had a cardiac device (5). Brennan et al, investigated patients from the Society of Thoracic Surgeons Adult Cardiac Surgery Database who underwent AVR from 1991 to 1999. They reported a higher risk of prosthetic valve endocarditis in patients with biological compared with mechanical valves (HR, 1.60; 95% CI, 1.31-1.94). American Journal of Medical Case Reports susceptible to bacterial implantation and provide a nidus for infection [3]

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