Abstract
AbstractThis chapter reviews the epidemiology and global distribution, modes of transmission, and control of Chagas' disease (caused by Trypanosoma cruzi). Novel approaches for the control of Chagas' disease are described, including paratransgenic control (in this approach, a symbiotic bacterium within a given disease vector is identified and genetically altered to produce molecules that kill the pathogen), antimicrobial peptides as effector molecules, recombinant single chain antibodies, and use of bacterial β-1,3-glucanase. Environmental consequences of deploying genetically altered lines of bacteria to target field populations of triatomine bugs are also discussed.
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