Abstract
The patient with a history of bone pain and muscle weakness, was thought to have oncogenic osteomalacia as a result of biochemical investigations and directed to Nuclear Medicine Department for a whole-body bone scintigraphy and 111In-octreotide scintigraphy. There was no focal pathologic tracer uptake, but generalized marked increase in skeletal uptake on bone scintigraphy. Octreotide scintigraphy showed accumulation of octreotide in the region of the left lobe of the thyroid gland in the neck. Thereafter, parathyroid scintigraphy was performed with technetium-99m labeled metroxy-isobutyl-isonitryl (99mTc-MIB) and MIBI scan demonstrated radiotracer uptake at the same location with octreotide scintigraphy. The patient underwent left inferior parathyroidectomy and histopathology confirmed a parathyroid adenoma. Somatostatin receptor positive parathyroid adenoma may show octreotide uptake. Octreotide scintigraphy may be promising and indicate a possibility of using somatostatin analogues for the medical treatment of somatostatin receptor positiveConflict of interest:None declared.
Highlights
111In-octreotide scintigraphy, based on the expression of somatostatin receptors by the tumor cells, is generally used to detect neuroendocrine tumors [1]
Octreotide scintigraphy rarely demonstrates an accumulation of radiotracer on parathyroid gland
Afterwards, Faggiano et al reported in their study which investigated the effectiveness of therapy with somatostatin analogues on primary hyperparathyroidism, that octreotide scintigraphy showed positive parathyroid tumor uptake in three of eight patients with Multiple Endocrine Neoplasia (MEN) 1 syndrome [7]
Summary
Seyhan Karaçavuş1, Mustafa Kula2, Züleyha Cihan Karaca2, Kürşad Ünlühızarcı2, Ahmet Tutuş2, Fahri Bayram2, Ganime Çoban3 1Bozok University School of Medicine, Nuclear Medicine Department of, Yozgat, Turkey 2Erciyes University School of Medicine, Endocrinology Department of, Kayseri, Turkey 3Erciyes University Erciyes School of Medicine, Pathology Department of, Kayseri, Turkey
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