Abstract
Parathyroid function was determined in four adults and one child with familial vitamin-D-resistant rickets. All subjects demonstrated hypophosphatemia, whereas the total serum calcium and magnesium showed no consistent pattern as compared to normal subjects. Peripheral parathyroid hormone concentrations were elevated in all subjects. Hypocalcemia induced by sodium ethylenediaminetetra-acetic acid in three adults produced a greater increase in parathyroid hormone secretion than in normal subjects. The increased concentrations of parathyroid hormone, both basal and during induced hypocalcemia, are consistent with Albright's hypothesis that the hyperparathyroidism in these subjects is due to decreased absorption of calcium from the gastrointestinal tract. (N Engl J Med 289:941–945, 1973)
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