Abstract
The effect of cortisol pretreatment on parathyroid hormone and thyrocalcitonin function has been studied. Male rats (weighing approximately 200 g) were either parathyroidectomized or thyroidectomized. The parathyroids in thyroidectomized rats had been previously transplanted. Peritoneal lavage was performed 18 hr after parathyroidectomy and 48 hr after thyroidectomy. For parathyroidectomized rats, the lavage fluid contained no calcium, causing calcium withdrawal from the body. For thyroidectomized rats, the fluid contained 12 mg Ca/100 ml, causing transfer of calcium into the animal. These techniques have been used to demonstrate the antagonistic effects of parathyroid hormone and thyrocalcitonin on calcium mobilization. Cortisol was administered for 5 days (5 mg/kg/day) and reduced the normal weight gain 20%. Normal animals with and without cortisol treatments served as controls. It is concluded that parathyroid hormone and thyrocalcitonin were able to maintain their normal physiological functions in the presence of this pharmacological dose of cortisol. However, the steroid did affect the results by decreasing the rate of removal of radioactivity which had been in the bone for 2 or more weeks. (Endocrinology86: 1080, 1970)
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