Abstract
Tests were done in growing rats to see whether the osteosclerotic changes provoked by parathyroid extract could be due to a compensatory secretion of calcitonin. Parathyroid extract increased metaphyseal bone in both intact and thyroparathyroidectomised animals. Likewise, peptide-pure parathyroid hormone induced similar changes in thyroparathyroidectomised rats. Incorporation of 3H-proline into bone hydroxyproline in these animals was strikingly augmented. It is concluded that (1) parathyroid-extract-induced osteosclerosis is not due to compensatory changes in calcitonin secretion; (2) parathyroid hormone itself, and not a contaminating peptide, is the cause; and (3) parathyroid hormone induces osteosclerosis by increasing bone formation, unlike calcitonin which does so by inhibiting bone resorption.
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