Abstract
In view of Collip's recent work, the case reported here, in which parathyroid extract was used, will probably be of interest to the medical profession. A woman, aged 54, came to the Mayo Clinic in July, 1921, complaining of a large goiter of twenty years' duration, and arthritis of five years' duration. On physical examination she appeared extremely nervous, with a warm moist skin, a positive Graefe's sign and a fine tremor of the hands. The pulse rate was 140; the systolic blood pressure was 170, the diastolic, 95. There were multiple adenomas of the thyroid; the right lobe measured 7.5 by 5 cm. and the left 5 by 5 cm.; no bruits or thrills were detected. The joints, particularly of the upper extremities, showed a moderate chronic infectious arthritis. Two teeth showed periapical infection; the tonsils were apparently normal. Urinalysis, blood count, Wassermann test, and electrocardiograms were negative. Roentgenograms
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