Abstract
1. DDT and parathion (100–500 μM) induced small contractures in molluscan columella muscle, and caused a significant stimulation of the slow component of 45Ca efflux from the whole fibres. Neither insecticide appeared to affect the initial fast efflux component. 2. These insecticides strongly inhibited both active and passive binding of calcium by isolated mitochondria and submembrane vesicles, while they induced a stimulation of calcium efflux from these subcellular fractions under in vitro conditions. 3. It is suggested that these insecticides induce contractures in molluscan smooth muscle by mobilizition of calcium from both the mitochondrial and submembrane vesicular storage sites.
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