Parasite glycoconjugates. Part 12.1 Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating α-D-mannopyranosylphosphate transferase in the Leishmania

Abstract

A set of phosphodisaccharides, structural analogues of the β-D-galactosyl-(1→4)-α-D-mannosyl phosphate 1, are synthesized using the Koenigs–Knorr method for the glycosylation reactions and the glycosyl hydrogenphosphonate method for phosphorylation. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania α-D-mannosylphosphate transferase.