Abstract
We investigated the relationship between microstructure of β-parapapillary atrophy (β-PPA) and morphologic features of optic nerve head (ONH) and posterior pole in highly myopic eyes. Eighty-nine highly myopic eyes were included in this study. Bruch’s membrane opening (BMO) area, lamina cribrosa (LC) thickness, anterior laminar depth, peripapillary and subfoveal choroidal thickness (CT), macular Bruch’s membrane (BM) length, and width of β-PPA with and without Bruch’s membrane (PPA+BM and PPA−BM) were evaluated. The mean age and axial length of the included subjects were 26.88 ± 2.44 years and 27.03 ± 0.88 mm, respectively. The width of PPA−BM was larger with increasing BMO area (P = 0.001), whereas the BMO area was not associated with the width of PPA+BM. The large PPA+BM was significantly related to a thinner LC (P = 0.003), deeper anterior lamina surface (P < 0.001), longer macular BM length (P = 0.008), and thinner temporal peripapillary CT (P = 0.034). We found that the morphologic features of the ONH and posterior pole in highly myopic eyes were different based on the microstructure of β-PPA. Whether these features are linked to the development of glaucoma in myopic eyes should be investigated in future studies.
Highlights
We investigated the relationship between microstructure of β-parapapillary atrophy (β-PPA) and morphologic features of optic nerve head (ONH) and posterior pole in highly myopic eyes
Interobserver agreement, determined using Bland-Altman plots, in the measurements of PPA+Bruch’s membrane (BM) width, PPA without BM (PPA−BM) width, lamina cribrosa (LC) thickness, macular BM length, and peripapillary and subfoveal choroidal thickness (CT) for all the subjects showed no systematic differences in measurements
The microstructure of β-PPA was different among the 81 eyes; 19 eyes had only PPA−BM, whereas 62 eyes had PPA with BM (PPA+BM) in their β-PPA area
Summary
We investigated the relationship between microstructure of β-parapapillary atrophy (β-PPA) and morphologic features of optic nerve head (ONH) and posterior pole in highly myopic eyes. We found that the morphologic features of the ONH and posterior pole in highly myopic eyes were different based on the microstructure of β-PPA Whether these features are linked to the development of glaucoma in myopic eyes should be investigated in future studies. We hypothesized that morphologic features of the optic nerve head (ONH) and the posterior pole might give clues to the mechanisms of differential developments of β-PPA in myopic eyes. The purpose of this work was to investigate the relationship between microstructure of β-PPA and the morphologic features of ONH and posterior pole in highly myopic eyes and to determine the mechanism of differential developments of β-PPA in myopic eyes
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