Abstract
Oxidative stress is an important factor in the development of atherosclerosis. Paraoxonase 1 (PON1), an enzyme associated with HDL, has been reported to have important antioxidant, anti-inflammatory, and cardioprotective actions, and the genetic deletion of PON1 is associated with increased atherosclerosis in animal models. Little is understood, however, about the relation between genetic polymorphisms of PON1 …
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