Paraneoplastic neuropathies. Antibodies spectrum

Abstract

Small-cell lung cancer (SCLC) sometimes is associated with paraneoplastic neurological autoimmunity. Different antibodies have been used for diagnosis of this condition and for diagnosis and signs of therapy results. Therefore various types of antibodies play a pathogenic role in mechanisms of autoimmune processes in paraneoplastic neuropathies (PN). Under our observation were 59 patients with different type of PN, 37 from them suffered from SCLC with paraneoplastic neuropathies, and 11 from Gullian-Barre syndrome. Control group consists of 246 neurologically healthy donors. Cerebrospinal fluid (CSF) was obtained from urological patients during spinal anesthesia and consequent surgeries. We used ELISA and Western Blot analysis for detection of anti-myelin-associated glycoprotein antibodies (MAG), anti-ganglioside antibodies. which are principally associated with autoimmune peripheral neuropathies and anti-glutamic acid decarboxylase antibodies in serum and CSF of all patients and control group. Besides this AB against urinergic receptor channel P2X purinoceptor 7 (P2X7), the voltage-gated potassium channel KV1.3 and the voltage-gated sodium channel NaV1.7 as examples of targeting ion channels were studied. It was revealed that in 78 per cent of PN all AB were increased two and three-fold. Ion channels AB were especially raised. In conclusion, we can state that antibody response plays a key role in pathogenesis of all autoimmune neuropathies. Paraneoplastic pathology in this regard is essential. Future research has to be done consider ion channel involvement and autoimmune reactivity toward them.