Abstract
Paraneoplastic neurological syndromes (PNS) are neurological disorders that occur as indirect immune-mediated responses to malignancies. The increased number of patients with PNS correlates with the discovery of an increasing number of novel autoantibodies associated with PNS. The use of immune checkpoint inhibitors that have expanded the range of cancers strongly associated with PNS has likely increased the frequency of PNS diagnoses. This article presents an overview of the pathophysiology, diagnosis, therapy, and prognosis of PNS.
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