Abstract
The idea that the degree of hypertension (HT) is a predictor of end organ damage and has a prognostic value is widespread and well established, but the assumption that BP variability (BPV) has the same relevance is new. The purpose of this study was to analyze the relationship between BPV determined using ABPM and arterial stifness measured using pulse wave velocity (PWV) in a group of patients with newly diagnosed HT starting from the hypothesis that there is a correlation between vascular damage and BPV. The study enrolled 60 subjects with newly diagnosed and untreated hypertension. The evaluation included medical history, demographics, lifestyle, family history (FH) of hypertension, physical examination, current chronic treatments. All subjects underwent ABPM and blood tests (serum creatinine, total cholesterol, blood glucose and uric acid). We calculated: standard deviation (SD), coefficient of variation (CV), excursion (E) for SBP (s), DBP (d), daytime SBP and daytime DBP, nocturnal SBP and nocturnal DBP. The patients were divided into quartiles of systolic BPV, diastolic BPV, diurnal and nocturnal systolic and diastolic BPV. Results: The mean age of patients was 60.56 +/- 6.76 years; 43.33% of patients were male; 66.66% had FH of HT. The average value of seric cholesterol was 186.8 +/- 45.20 mg / dl; the average value of creatinine was 1.08 +/- 0.21 mg/dl, the average value of uric acid was 5.14 +/- 1.33 mg / dl. The average value of PWV was 89.48 +/- 4.66 cm/s. PWV was statistically significant different between SD quartiles of systolic BP at night, coefficient of variation quartiles of systolic BP at night and nocturnal systolic BPV. Also, PWV was different between E quartiles and CV quartiles of systolic BP. In linear regression, statistical significance was obtained for total cholesterol, E of nocturnal SBP, CV of nocturnal SBP and systolic BPV. In multiple linear regression obtained after excluding the independent variables with high collinearity (CV of nocturnal SBP) we achieved statistical significance for high level of seric cholesterol and nocturnal systolic BPV. The data obtained came to strengthen the data in the literature, that an increased value of seric cholesterol is a major determinant of arterial stiffness.
Highlights
The idea that the degree of hypertension (HT) is a predictor of end organ damage and has a prognostic value is widespread and well established, but the assumption that BP variability (BPV) has the same relevance is new
V TA s în grupul de studiu a fost 277,02 +/- 109,19 mmHg2,V TA d a fost 96,95 +/- 47.35 mmHg2, V TA s diurne în grupul de studiu a fost 186,22 +/- 88,05 mmHg2, V TA d diurne în grupul de studiu a fost 72,73 +/- 45,18 mmHg2, V TA s nocturne în grupul de studiu a fost 194,64 +/- 99,89 mmHg2, V TA d nocturne în grupul de studiu a fost 77,61 +/- 47,51 mmHg2
Datele obţinute pentru colesterol vin să întărească datele din literatură că valoarea crescută a colesterolului este un determinant major al rigidităţii arteriale
Summary
PARAMETRII VARIABILITĂŢII TENSIUNII ARTERIALE ŞI AFECTAREA VASCULARĂ ÎN HIPERTENSIUNEA ESENŢIALĂ. Studiul de faţă îşi propune analiza relaţiei dintre VTA determinată prin MATA şi afectarea arterială măsurată prin velocitatea undei pulsului (PWV) în cazul unui grup de pacienţi nou diagnosticaţi cu HTA pornind de la ipoteza corelării VTA cu afectarea vasculară. Colesterolul mediu a fost 186,8 +/- 45,20 mg/dl, creatinina medie 1,08 +/- 0,21 mg/dl, media acidului uric a fost de 5,14 +/- 1,33 mg/dl. În regresia lineară semnificaţie statistică s-a obţinut pentru colesterolul total, E TA s nocturnă, CV a TA s nocturnă şi V TA s nocturnă. În regresia multilineară obţinută după excluderea variabilelor independente cu colinearitate mare (CV a TA s nocturne) am obţinut semnificaţie statistică pentru colesterol şi V TA s nocturne. Datele obţinute pentru colesterol vin să întărească datele din literatură că valoarea crescută a colesterolului este un determinant major al rigidităţii arteriale
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
