Parametric investigation of an injection-jet self-powered Fontan circulation

Ray Prather,Arka Das,Eduardo Divo,Michael Farias,William Decampli,Alain Kassab

doi:10.1038/s41598-022-05985-3

Abstract

Approximately 1/2500 babies are born with only one functioning ventricle and the Fontan is the third and, ideally final staged palliative operation for these patients. This altered circulation is prone to failure with survival rates below 50% into adulthood. Chronically elevated inferior vena cava (IVC) pressure is implicated as one cause of the mortality and morbidity in this population. An injection jet shunt (IJS) drawing blood-flow directly from the aortic arch to significantly lower IVC pressure is proposed. A computer-generated 3D model of a 2–4 year old patient with a fenestrated Fontan and a cardiac output of 2.3 L/min was generated. The detailed 3D pulsatile hemodynamics are resolved in a zero-dimensional lumped parameter network tightly-coupled to a 3D computational fluid dynamics model accounting for non-Newtonian blood rheology and resolving turbulence using large eddy simulation. IVC pressure and systemic oxygen saturation were tracked for various IJS-assisted Fontan configurations, altering design parameters such as shunt and fenestration diameters and locations. A baseline “failing” Fontan with a 4 mm fenestration was tuned to have an elevated IVC pressure (+ 17.8 mmHg). Enlargement of the fenestration to 8 mm resulted in a 3 mmHg IVC pressure drop but an unacceptable reduction in systemic oxygen saturation below 80%. Addition of an IJS with a 2 mm nozzle and minor volume load to the ventricle improved the IVC pressure drop to 3.2 mmHg while increasing systemic oxygen saturation above 80%. The salutary effects of the IJS to effectively lower IVC pressure while retaining acceptable levels of oxygen saturation are successfully demonstrated.

Highlights

A structurally normal heart consists of two separate ventricles, one pumping de-oxygenated blood returning from the body to the lungs, and the other pumping oxygenated blood from the lungs to the body
Models demonstrating a 3.2 mmHg inferior vena cava (IVC) pressure drop with a systemic oxygen saturation greater than 80%, while retaining a constant pulmonary vascular resistance (PVR), were discovered
This paper presents a comprehensive study that reveals a significant IVC pressure drop by means of an injection jet shunt in computational models of the failing Fontan

Summary

Introduction

A structurally normal heart consists of two separate ventricles, one pumping de-oxygenated blood returning from the body to the lungs, and the other pumping oxygenated blood from the lungs to the body. At Stage 1 the vasculature is reconstructed to assure unobstructed and roughly equal flow to both the lungs (“pulmonary circulation”) and body (“systemic circulation”), both circulations powered “in parallel” by the ventricle. At this stage, the ventricle’s volume load is roughly twice normal, increasing the strain on the myocardium, and systemic oxygen delivery is below normal because oxygenated blood mixes with deoxygenated blood in the ventricle. Systemic oxygen content is closer to normal with the majority of venous return going through the lungs rather than returning to the systemic circulation This is typically called the “Fontan circulation”. Even with normal pulmonary vascular resistance (PVR), vena cava pressure (Pfontan) must rise from its usual value of 3–6 mmHg to values of 10–14 mmHg

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