Parametric estimation of quality adjusted lifetime (QAL) distribution in progressive illness–death model

Abstract

In this work, we consider the parametric estimation of quality adjusted lifetime (QAL) distribution in progressive illness-death models. The main idea of this paper is to derive the theoretical distribution of QAL for the progressive illness-death models, under parametric models for the sojourn time distributions in different states, and then replace the model parameters by their estimates obtained by standard techniques of survival analysis. The method of estimation of the model parameters is also described. A data set of IBCSG Trial V has been analyzed for illustration. Extension to more general illness-death models is also discussed.