Parameters of Spermatogenesis and Hormonal and Metabolic Statuses in Men of Different Age Groups from Northern European Russia

Abstract

Process of male aging involves structural and functional changes in many organs and systems, including the reproductive system. The aim of this study was to investigate semen parameters and reproductive hormone and metabolite levels in men of different age groups living in the northern European Russia (the city of Arkhangelsk). The study included 99 men aged from 21 to 63 years. Retrospectively, the participants were divided into four groups according to their age: 21–30, 31–40, 41–50, and 51–63 years. It was found that the semen parameters did not differ among different age groups. Distinct age-related changes were observed in the inhibin B and follicle-stimulating hormone (FSH) levels. Linear regression analysis showed that the FSH level increased by 2.0% and the inhibin B level decreased by 1.0% every year. An increase in the waist circumference by 0.2% a year was shown, which was accompanied by an increase in the total cholesterol level by 0.4% every year. Our findings illustrate the functional weakening of the hypothalamic–pituitary axis as a first predictor of reproductive aging in men from the northern European Russia after the age of 50 years.