Abstract
Background and Objectives: Patients with acute myocardial infarction (MI) are usually treated with percutaneous transluminal coronary angioplasty (PTCA), which is burdened with a risk of postoperative complications, often accompanied by biochemical disturbances. The aim of our study was to evaluate a set of selected parameters of oxidative and inflammatory status, which could be useful in the management of post-procedural care in MI patients after PTCA. Materials and Methods: In this preliminary study, ischemia modified albumin (IMA), advanced oxidation protein products (AOPP), thiol groups (SH), total antioxidant status (TAS), insulin growth factor-1 (IGF-1), presepsin (PSP), and trimethylamine N-oxide (TMAO) were chosen as candidate biomarkers, and were determined in patients with MI who underwent PTCA at two time points: During cardiac episodes (at admission to the hospital, T0) and 3 months later (T3). Results: Most of the examined parameters were significantly different between patients and control subjects (except for IMA and TAS), but only hsCRP changed significantly during the time of observation (T0 vs. T3). Discriminant analysis created a model composed of AOPP, hsCRP, PSP, and TMAO, which differentiated male subjects into a group with MI and a control (without cardiovascular diseases). Conclusion: This set of parameters seems useful in evaluating inflammatory and oxidative status in MI patients after PTCA.
Highlights
Cardiovascular diseases (CVDs) are widespread in modern societies, constituting one of the leading causes of death all over the world
Based on analysis performed in subgroups of patients with normal and decreased left ventricular (LV) ejection fraction (EF) (Table 3), we suggest that ischemia modified albumin (IMA) may serve as an additional marker in the evaluation of patient states, but only in groups with the preserved function of the left ventricle
myocardial infarction (MI), we investigated high-sensitivity C-reactive protein (hsCRP) and presepsin concentrations, as old and new parameters in CVD
Summary
Cardiovascular diseases (CVDs) are widespread in modern societies, constituting one of the leading causes of death all over the world. Their development is influenced by so-called cardiovascular risk factors, out of which lipid disorders, hypertension, diabetes, and tobacco smoking remain the most important [1,2]. The role of insulin growth factor 1 (IGF-1) in CVD is still controversial It was initially considered one of the factors in the development of atherosclerosis, due to the intensification of vascular proliferation and migration of smooth muscle cells, but some research indicates its cardioprotective role and association with lower mortality risk from CVD outcomes [15,16].
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