Abstract
Abstract Parameters that yield optimum separations in field-flow fractionation (FFF) are investigated. Expressions for minimum plate height and optimum velocity are derived. It is shown that a typical FFF column is theoretically capable of yielding 12,000 plates per foot. With increasing retention, plate height decreases and optimum velocity increases. Minimum time conditions, analyzed next, are related to the rate of generation of theoretical plates. The latter increases with the rate of molecular transport and, surprisingly, with retention. Practical hurdles to achieving an infinite rate of generation of plates by going to infinite retention are discussed. Finally, a comparison is made between optimum separations using FFF and using direct fields (electrophoresis, sedimentation, and related methods.)
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