Abstract
Parameter estimations were made for the reversed-phase adsorption of perillyl alcohol (POH), a potent anti-cancer agent, on octadecylsilyl-silica gel (ODS). The average particle diame- ter of ODS was about 15 µm, and the particles were packed in the column (3.9 × 300 mm). The mobile phase used was a mixture of acetonitrile and water, in which the acetonitrile ranged be- tween 50 and 70 (v/v %). The first absolute moment and the second central moment were deter- mined from the chromatographic elution curves by moment analysis. Experiments were carried out using POH solutions within the linear adsorption range. The fluid-to-particle mass transfer coefficient was estimated using the Wilson-Geankoplis equation. The axial dispersion coefficient and the intraparticle diffusivity were determined from the slope and intercept of a plot of H vs 1/u0, respectively. The contributions of each mass-transfer step were axial dispersion, fluid-to- particle mass transfer, and intraparticle diffusion.
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