Abstract

Homozygous beta thalassemic sera show an electron spin resonance (ESR) signal at g approximately equal to 6 which is not present in normal and heterozygous sera. The signal arises from high spin heme groups exhibiting a departure from tetragonal symmetry toward rhombic. Binding by a serum protein is very likely responsible for such a distortion. In contrast with other authors' findings, we report that heme-human albumin complex shows a similar rhombic distortion. The observed ESR signal at g approximately equal to 6 is then attributed to this complex.

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