Abstract
Combinatorial and parallel synthesis technologies have become an integral part of many discovery research organizations. This paper will discuss DuPont's entry into this field and how our strategies to capture the best value from these technologies have evolved. Applications to both lead discovery and lead optimization programs will be presented with examples taken from DuPont's fungicide, herbicide and insecticide programs. Technologies illustrated include parallel solid phase and solution phase synthesis, mixture synthesis, multi-component reactions and the design and use of combinatorial libraries. The use of contract research organizations as a way to leverage internal resources will also be discussed.
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