Abstract
Gold nanorods show intense two photon luminescence arising from surface plasmon resonances (SPRs). Such SPRs exhibit a strong dependence on the environmental conditions and can be used to detect interactions between a nanorod and single biomolecules. Here we report a novel technique to acquire excitation spectra of multiple single gold nanorods in parallel, within a few seconds. We acquired two-photon excitation spectra of tens of single gold nanorods, and analyzed individual gold nanorod features. 3-dimensional fitting yields a spectral resolution of 1 nm. This allows for discriminating between single and multiple gold nanorods, as well as analysis of spectral changes in time. Using this technique we aim to detect single protein-gold nanorod interactions within a living cell.
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