Abstract
Metabolomics Uncharacterized gene sequences are annotated based on the function of distant relatives and often have very different functions in reality. Kim et al. developed a method based on untargeted metabolomics to fill in the gaps and assign precise function to members of the M20 peptidase family, which generally catalyze amide bond cleavage. Viral transduction of each enzyme in mice and comparative analysis of levels of metabolites in liver tissue recovered known enzyme functions for two family members and assigned a new function, dipeptide cleavage, for one of the orphan enzymes in this family. Cell Chem. Biol. 10.1016/j.chembiol.2019.09.009 (2019).
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