Abstract
A hybrid CPU-GPU approach is used to investigate the patterns of blood flow and magnetic particles numerically in a capillary under the existence of constant magnetic field. However, the blood flow is considered to be Newtonian, laminar and incompressible in the capillary and magnetic Nanoparticles are assumed as potential agent carrier being used therapeutically for the magnetic targeted drug transport in the fight against diseased cells. The magnetic field is embedded in the muscular volume and is produced by a permanent magnet. The flow field and particles transport dynamics are formulated by a mathematical model and is solved numerically. Finite element discretization gives a big sparse system of equations which needs a higher computation. Therefore, the hybrid approach deals the extensive computations in parallel, as this is a good platform which can decrease the times of solution significantly, if compared to the CPU application. This serves for highly effective search for distinctive mathematical model, along with their distinctive parameters. The impact of pressure P, the capillary radius R; the magnetic nanoparticle radius RM, the magnetic field intensity H on the blood flow along with magnetic particles is studied with regard to the inputs and model of magnetic field. The mathematical results for both the velocity of particles and blood are calculated. It is observed that magnetic field is directly proportional to the flow pattern as an increase in the former upsurge the latter. Moreover, the distance between magnet and capillary wall exerts a direct influence on velocity and is helpful to pull magnetic nanoparticles to the capillary wall. Thus, it is concluded by simulation that the magnetic parameters govern the velocity profile.
Highlights
M agnetic Drug Targeting (MDT) is a significant proposed method for handling cancer like localized abscesses
FEM is used to calculate the velocity trends of blood and particles and computed data is showed for diverse time values, pressure gradient ∇P, magnetization M, magnetic field intensity H and distance (y) between the capillary surface and the magnet
Variation from 0.05 to 0.15 cm/sec of velocity of blood in capillary is noted by experiments which agrees with the results given in graphs. Magnetic nanoparticles, it is showed in graphs, travel a very successful journey to the targeted location along with blood to transport the drug
Summary
M agnetic Drug Targeting (MDT) is a significant proposed method for handling cancer like localized abscesses. The drug propagates through the cardiovascular system in non-targeted therapy of drug, directing little concentrations in the abnormal tissue while showing adverse effects in normal tissue. MDT struggles to resolve this issue non-invasively by steering magnetically the therapeutic particles to the targeted. A perfect MDT therapy starts either attaching the therapeutic chemically to magnetic particles or entering in a drug carrier. The magnetic therapeutic particles (drug) are be inserted into the bloodstream at a suitable position while outwardly-applied magnetics field directs them towards the unhealthy tissue, and are forced into the capillary bed of the diseased site, where these particles could be triggered by pH, temperature, magnetic trigger or an enzyme [1]. The above process is challenging partially as the behaviour of magnetic particles is not well understood in blood
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