Abstract
The bindings of small molecular oxazine750 to d[TG4T]4,d[G4T4G4]2 and c-myc sequences was characterized by means of circular dichroism,thermal denaturation,and so on.Oxazine750 was found to bind preferentially and strongly to parallel G-quadruplex.It can effectively stabilize the parallel G-quadruplex and destabilize the antiparallel G-quadruplex.The melting temperature of d[TG4T]4 or c-myc is increased by about 11 ℃ or 40 ℃ by oxazine750,respectively.Under the same condition,oxazine750 decreased the melting temperature of d[G4T4G4]2 by about 8 ℃.
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