Abstract
A new technique for the refractive index change with high-sensitivity measurements was proposed by the digital image of porous silicon (PSi) microarray utilization in this paper. Under the irradiation of a He-Ne laser, the surface images of the PSi array cells with the microcavity structure were obtained by the digital imaging equipment, whereas the refractive index change of each array cells was detected by calculating the average gray value of the image and the refractive index change measurement sensitivity was 10−4 order of magnitude. This technique could be utilized in the label-free and parallel detection of refraction index changes induced by a biological reaction in the microarray or the chip.
Highlights
The biochip constitutes a new technology, which is developed from the research and development of the human genome project
A new method of the refractive index change measurement of a porous silicon microcavity (PSM) microarray based on image gray level change detection was proposed
The refractive index change in the array cell could be obtained by the laser incident angle adjustment
Summary
The biochip (microarray) constitutes a new technology, which is developed from the research and development of the human genome project. It is an effective method for biological information to be obtained efficiently [1,2]. Syshchyk et al [16] enhanced the reflectance spectra of multilayer porous porous the 33-array detection of human immunoglobulin achieved. A measurement method for for the the refractive index of the porous silicon microcavity (PSM). Detection of refractive index change in the PSM microarray was implemented by by image gray measurement, combining the optical characteristics and digital image processing image gray measurement, combining the optical characteristics and digital image processing technology technologyof ofan anarray arraycell cellPSM. Of the label-free array based on the image gray scale was developed
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