Abstract

We present new parallel algorithms for 3D reconstruction of objects from 2D projections and their application for the determination of the structure of macromolecules from electron micrographs. A multi-resolution orientation determination algorithm uses a parallel search to determine the 'best fit' of a given image with images in a reference database. The 3D reconstruction algorithm uses Cartesian coordinates and permits the reconstruction of objects that do not possess symmetries. The method decomposes a large linear system into a set of smaller systems that can be solved independently on different processors of a parallel computer or on a cluster of workstations. The paper outlines the reconstruction process and the data partitioning and load balancing issues pertinent to the parallel implementation of the algorithm; preliminary results obtained on a SGI Origin 2000 system are given.

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