Abstract
Localized lesions were produced in the cerebral cortices of rats by application of low temperatures to the intact skull. In animals killed 2 months after the injury, the reparative response observed involved axons and neuroglia cells. Polarizing microscopy indicated the presence of appreciable bundles of myelinatedfibers in the paralesional region. The myelinated nature of these fibers was corroborated by conventional myelin stains, phase contrast study of PPDA thick sections, and electron microscopy. Intense astrocytic gliosis was present. The nature of the glial processes in close association with the remyelinating axons and the relative participation of the different types of neuroglia in the reparative response are considered.
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