Abstract
The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1–12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.
Highlights
While natural product research includes plant, marine animal and microbe sources, more recently, marine flora and fauna have afforded an exciting number of potential therapeutic agents that are currently in preclinical and clinical evaluation due to promising biological activities with in vivo and in vitro assays [1,2,3,4,5,6,7]
Such drug leads have significantly contributed to our understanding of cellular biochemical processes
Typical marine skeletons combined with robust biological activities have attracted the attention of pharmacists, chemists and biologists [8,9,10,11]
Summary
While natural product research includes plant, marine animal and microbe sources, more recently, marine flora and fauna have afforded an exciting number of potential therapeutic agents that are currently in preclinical and clinical evaluation due to promising biological activities with in vivo and in vitro assays [1,2,3,4,5,6,7]. Such drug leads have significantly contributed to our understanding of cellular biochemical processes.
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