Abstract
Paraganglioma-like dermal melanocytic tumor is a rare subtype of benign dermal melanocytic tumors. Its histopathologic features resemble those of paraganglioma, but the immunostaining characteristics are those of melanocytic lesions.We report a case of a 60-year-old male with a paraganglioma-like dermal melanocytic tumor of his left cheek and briefly review the English literature.
Highlights
A 60-year-old male presented with a skin-colored slightly raised soft 0.8 cm papule on his left cheek present for an unknown period of time
The neoplasm was composed of organoid and nested groups of large epithelioid cells separated by delicate fibrous strands and prominent blood vessels
paraganglioma-like dermal melanocytic tumor (PDMT) is considered as a unique benign neoplasm derived from melanocytes
Summary
A 60-year-old male presented with a skin-colored slightly raised soft 0.8 cm papule on his left cheek present for an unknown period of time. The clinical impression was a "skin tag". An excisional biopsy of the lesion showed a well demarcated cellular nodule in the dermis (Fig. 1) with normal overlying epidermis. The neoplasm was composed of organoid and nested groups of large epithelioid cells separated by delicate fibrous strands and prominent blood vessels. The epithelioid cells had distinct large nuclei with prominent red nucleoli and somewhat clear cytoplasm (Fig. 2). Some of the large epitheliod cells had multiple nuclei and vacuoles. There was one area of the tumor showing nests of mature nevus cells. The neoplasm was immunoreactive for Melan-A, MITF, and S-100 protein (Fig. 3) indicating melanocytic lineage of the tumor cells. The tumor cells were negative for CD31, CD34, CD68, cytokeratin AE 1/3 and HMB-45
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