Abstract
Using a method of EEG analysis previously described, the effects of hyperosmotic and hypo-osmotic compounds injected intraperitoneally are studied. It is shown that the effects of both types of osmotic stressing cause similar types of response when the EEG is evaluated using this algorithm. It is shown that the hyperosmotic agent used (glucose and water) was more effective on a volume basis than the hypo-osmotic agent (distilled water). The changes in EEG activity with osmotic stressing show a quantitative response (i.e., the larger the dosage of osmotic agent the higher the response as scored using the algorithm). It is suggested that this algorithm may be useful in evaluating the changes in electrical activity in experimental animals while undergoing drug response evaluation.
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