Paradox of Protection: Preferential Recognition of CD4-induced Epitopes by Anti-HIV-1 ADCC Antibodies

Matthew S Parsons,Stephen J Kent

doi:10.1016/j.ebiom.2015.09.048

Abstract

Paradox of Protection: Preferential Recognition of CD4-induced Epitopes by Anti-HIV-1 ADCC Antibodies

Highlights

Utilizing this technology, Williams et al identified three antibodydependent cellular cytotoxicity (ADCC) antibodies from an HIV-1 subtype A-infected donor
Both Vpu and Nef downregulate cell surface CD4 and prevent Env from entering the CD4-bound conformation prominently targeted by ADCC antibodies (Veillette et al, 2014, Veillette et al, 2015)
The Vpu and Nef-mediated down regulation of CD4 at first blush appears paradoxical to the notion that ADCC antibodies targeting the CD4

Summary

Introduction

Williams et al identified three ADCC antibodies from an HIV-1 subtype A-infected donor. Much evidence points towards a role for Vpu and Nef in the evasion of ADCC responses by HIV-1-infected cells Both Vpu and Nef downregulate cell surface CD4 and prevent Env from entering the CD4-bound conformation prominently targeted by ADCC antibodies (Veillette et al, 2014, Veillette et al, 2015).

Results

Conclusion