Paradigm change to cost-effective predictive and preventive medicine: individual profiling of healthy vasospastic individuals for targeted prevention as the cost-effective personalised medicine

Abstract

Vascular deregulation (VD) or Vasospastic Syndrome is defined as an inappropriate constriction or insufficient dilatation in the microcirculation. Primary VD is highly prevalent in subpopulations of young people and can potentially predispose healthy individuals to severe disorders (neurodegeneration and cancer) being, therefore, particularly attractive for predictive diagnostics and primary prevention in targeted sub-populations [1], namely it occurs more frequently in females and is manifested at puberty, moderating with age this phenomenon is even more frequent in the Japanese population compared to Caucasians usually, academics are more affected by VD in addition to clinical signs there is an inborn increased sensitivity to any kind of stress provocation (mechanical, cold, emotion, etc.), altered drug sensitivity, frequently cold extremities, altered sleep behaviour, reduced feeling of thirst but increased smell perception, low blood-pressure, reduced body-mass-index, more frequent migraine compared to general population Compared to the general population, vasospastic individuals tend to have a meticulous personality and successful professional career, Figure 1. Open image in new window Figure 1 Symptoms and typical attitude of individuals with Vasospastic Syndrome: individuals with primary vasospastic deregulation tend to a meticulous personality and successful professional career such as the young female on the left image [2]