Abstract
The relationship between brain serotonin levels and habituation of a skeletal-motor startle response was studied using parachlorophenylalanine (PCPA), a drug which inhibits the formation of serotonin. Depletion of brain serotonin by PCPA slows down, but does not prevent, habituation. PCPA given to rats that were habituated before starting drug treatment causes a transitory increase in startle response magnitude. Whether PCPA is administered before or after habituation, the treated rats exhibit heightened reactivity to startle stimuli following exposure to novel stimuli. These results suggest that brain serotonin plays a role in inhibitory processes.
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