Abstract
Ceylon Medical Journal (CMJ) is a peer-reviewed, open access journal published quarterly by the Sri Lanka Medical Association in the last week of March, June, September and December each year. The mission of the CMJ is to promote the science and art of medicine and betterment of public health. The Journal publishes original papers and commentaries which have relevance to medicine and allied sciences. The CMJ is committed to maintaining and conforming to the editorial and ethical standards recommended by the International Committee of Medical Journal Editors.
Highlights
Assistant Editors Malik Goonewardene MS, FRCOG Renuka Jayatissa MD, MSc Udaya K Ranawaka MD, FRCP Carukshi Arambepola MBBS, MD Chandu de Silva MBBS, MD Samath Dharmaratne MSc, MD Tiran Dias MD, MRCOG Ranil Fernando FRCS, PhD Prasad Katulanda MD, DPhil Sarath Lekamwasam MD, PhD Senaka Rajapakse MD, FRCP Sisira Siribaddana MD, FRCP
In Sri Lanka paracetamol overdose has exponentially increased in urban and rural areas [5, 6]. It is responsible for 50% of admissions due to overdose in the National Hospital of Sri Lanka (National Poisons Information Center data), and on average two patients are admitted every day with paracetamol overdose [7]
Oral methionine is recommended for patients presenting within 8 hours and not having vomiting or history of liver disease as it is a more cost effective alternative in the absence of studies proving superiority of NAC [17, 18, 27, 28]
Summary
Established 1887 The Official Publication of the Sri Lanka Medical Association Volume 60, No., September 2015 Quarterly ISSN 0009–0875. Paracetamol overdose: Relevance of recent evidence for managing patients in Sri Lanka. In Sri Lanka paracetamol overdose has exponentially increased in urban and rural areas [5, 6]. It is responsible for 50% of admissions due to overdose in the National Hospital of Sri Lanka (National Poisons Information Center data), and on average two patients are admitted every day with paracetamol overdose [7]. Paracetamol toxicity is mostly due to the toxic intermediate metabolite N-acetyl-p-benzoquinone imine (NAPQI) produced by cyctochrome P450 enzymes This normally binds to sulfhydral groups in gluthathione to form non toxic metabolites.
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