Abstract
Paracetamol is a nonopioid synthesized p-aminophenol derivative that used as an antipyretic and an analgesic. Paracetamol is an over the counter medicine. 15.6% of migraine patients took paracetamol for headache relief. In migraine, paracetamol is used long term. This triggers paracetamol to cause Medication Overuse Headache (MOH). Animal studies associated paracetamol induced MOH based on pathophysiology migrenes. There three mechanism underline MOH include effect to korteks cerebral, effect to system trigeminal nociception, and effect to central modulating systems.
Highlights
Zainab Samaan, E Anne MacGregor, Dowson Andrew, Peter McGuffin, Anne Farmer. "Diagnosing migraine in research and clinical settings: The validation of the Structured Migraine Interview (SMI)", BMC Neurology, 2010.
Submission date: 23-Dec-2020 01:26PM (UTC+0800) Submission ID: 1480773203 File name: 2020-09-JPHV,_vol.1_Pct,_migraine_dll.pdf (323.91K) Word count: 4014 Character count: 24993
PARACETAMOL, MIGRAINE, AND MEDICATION OVERUSE HEADACHE (MOH)
Summary
Zainab Samaan, E Anne MacGregor, Dowson Andrew, Peter McGuffin, Anne Farmer. "Diagnosing migraine in research and clinical settings: The validation of the Structured Migraine Interview (SMI)", BMC Neurology, 2010.
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