Abstract
Antipyretic agents such as paracetamol or ibuprofen are routinely used in paediatric practice. They are sometimes used in combination, or even prophylactically, because of concerns about hyperthermia causing adverse events—such as febrile seizures or distress to the child. Available evidence published by the National Institute for Health and Clinical Excellence (NICE) suggests that antipyretic agents do not prevent febrile convulsions, and should not be used specifically for this purpose (NICE, 2010). It is also suggested not to administer paracetamol and ibuprofen at the same time, but to consider using the alternative agent if the child does not respond to the first drug (NICE, 2010).
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