Abstract
ObjectivesTo evaluate the association between sex-specific serum high sensitive C reactive protein (hsCRP) levels and NAFLD in a large population-based study.ResultsFrom Q1 to Q4, the incidence ratios were 21.1 (95% CI 17.5 24.7), 18.6 (95% CI 16.5 20.8), 24.8 (95% CI 22.4 27.2) and 31.1 (95% CI 28.5 33.6) in males and 6.2 (95% CI 4.4 8.0), 6.0 (95% CI 5.1 7.1), 11.4 (95% CI 9.2 13.7) and 19.5 (95% CI 16.1 22.9) in females. Compared with a 1.7-fold increase (Q4 vs Q2) in males, actuarial incidence increased 3.3-fold (Q4 vs Q2) in females. After adjusting for known confounding variables in this study, in the longitudinal population, compared with the reference group, those in Q1, Q3, and Q4 had HRs of 1.63 (95% CI 1.29-2.05), 1.11 (95% CI 0.93-1.31), 1.14 (95% CI 0.97-1.35) in male and 1.77 (95% CI 1.25-2.49), 1.22 (95% CI 0.93-1.59), 1.36 (95% CI 1.03-1.80) in female for NAFLD, respectively.Methods8618 subjects from Wenzhou Medical Center of Wenzhou People's Hospital were included. Sex specific hsCRP quartiles (Q1 to Q4) were defined: 0-0.1, 0.2-0.4, 0.5-0.8 and 0.9-25.9 for male; 0-0.1, 0.2-0.6, 0.7-1.2 and1.3-28.4 for female. Applying Q2 as reference, Hazard ratios (HRs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of hsCRP.ConclusionsWe report that a sex-specific hsCRP level is independently associated with NAFLD. The association between hsCRP and NAFLD was significantly stronger in females than in males.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease. 5% to 42% of the general population in Asian countries and 24% to42% in Western countries suffer from the disease [1,2,3]
From Q1 to Q4, the incidence ratios were 21.1, 18.6, 24.8 and 31.1 in males and 6.2, 6.0, 11.4 and 19.5 in females
We report that a sex-specific High sensitive C reactive protein (hsCRP) level is independently associated with NAFLD
Summary
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease. 5% to 42% of the general population in Asian countries and 24% to42% in Western countries suffer from the disease [1,2,3]. As is commonly associated with hypertension, obesity, insulin resistance, and dyslipidemia, NAFLD is the result of accumulated hepatic fat without excessive alcohol intake or other causes of liver disease [4, 5]. With NAFLD, www.impactjournals.com/oncotarget patients have a significantly higher risk of death compared with the general population [6, 7]. A large effort has been extended to investigate risk factors associated with NAFLD and recent studies have met with some success which has encouraged further work in this field [8, 9]. Other studies have reported that compared with males, the impact of elevated hsCRP level in cardiovascular disease is likely associated with a worse prognosis in women [13,14,15]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
