Abstract
Papillary thyroid microcarcinoma (PTMC) is a subset of papillary thyroid carcinoma, with tumors measuring ≤1.0 cm in maximum diameter. Esophageal squamous cell carcinoma (ESCC) is the most common histopathological subtype of the various esophageal malignancies. The present study reports a rare synchronous presentation of PTMC and asymptomatic ESCC manifesting as lateral cervical lymph node enlargement. The patient, a 70-year-old male who presented to the Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China)with no significant symptoms, was identified to have bilateral thyroid nodules by ultrasonography and enlarged lymph nodes on the left side of the neck by palpation. A diagnosis of PTMC with lateral cervical lymph node metastasis was established and the patient underwent right lobectomy, partial left lobectomy and lymph node biopsy. Pathological analysis of the intraoperative frozen biopsy indicated bilateral PTMC and metastatic lymph node SCC from a different primary location. Furthermore, histological examination of the biopsied lymph nodes revealed bilateral PTMC and poorly-differentiated SCC, which was verified as ESCC by gastroscopy and postoperative histopathological examination. A review of the present literature indicated that no similar case has been reported thus far. The patient succumbed three months after attending Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (Shanghai, China) for additional treatment.
Highlights
Papillary thyroid microcarcinoma (PTMC) is a subset of papillary thyroid carcinoma, with tumors measuring ≤1.0 cm in maximum diameter
The present study conducted a literature review, which indicated that no report currently exists documenting a simultaneous case of PTMC and Esophageal squamous cell carcinoma (ESCC) with no clinical manifestation, with the exception of lateral cervical lymphadenopathy
A 70‐year‐old male was admitted to the Department of Surgical Oncology (The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China) in November, 2011 with suspected PTMC and lateral cervical lymph node metastasis identified by careful digital palpation and ultrasonography (US) during a routine health examination
Summary
Papillary thyroid microcarcinoma (PTMC) is a subset of papillary thyroid carcinoma, with tumors measuring ≤1.0 cm in maximum diameter. Esophageal squamous cell carcinoma (ESCC) is the most common histopathological subtype of the various esophageal malignancies It is among the most aggressive types of cancer and is characterized by early‐stage lymph node metastasis as well as a high rate of mortality [3,4]. A 70‐year‐old male was admitted to the Department of Surgical Oncology (The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China) in November, 2011 with suspected PTMC and lateral cervical lymph node metastasis identified by careful digital palpation and ultrasonography (US) during a routine health examination. Subsequent histopathological examination confirmed the diagnosis of papillary thyroid microcarcinoma without extrathyroidal extension in the two lobes (Fig. 1B) and the histological type of the lymph node lesion was determined to be poorly‐differentiated SCC (Fig. 1C). The patient succumbed three months after attending Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (Shanghai, China) for radiotherapy
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