Abstract
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies with poor prognosis. Approximately 20 % of patients with ATC have a history of differentiated thyroid carcinoma, and 20 to 30 % have a coexisting differentiated thyroid carcinoma. We report a case of papillary thyroid carcinoma (PTC) with anaplastic transformation after follow-up for 17 years. Patient presented with an ulcerative mass over the previous surgical wound. Further examination revealed lung metastasis. Patient expired within half a year after ATC was diagnosed. Conventional therapies provide little aid in treating ATC. Multiple molecular abnormalities have been disclosed with the progression of normal follicular thyroid cells to ATC. This should provoke the development of innovative strategies beyond the conventional methods to overcome the lethal disease.
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