Abstract
Abstract Background: Squamous-cell carcinoma (SCC) is the most common type of cancer of the uterine cervix. It has several unusual histologic variants. The prognosis and treatment may vary with the histologic type. Papillary squamous-cell carcinoma (PSCC) is one of these unusual variants; it has been poorly reported in the literature. This subtype has distinctive histologic and clinical characteristics and differs from other papillary lesions of the cervix, including: condyloma; verrucous carcinoma; papillary immature metaplasia; and typical SCC. PSCC is characterized by the appearance of late recurrences and metastasis. The involvement of HPV in SCC pathophysiology is not well-established. PSCC is treated in a similar manner to the usual SCC; however PSCC is more sensitive to radiotherapy than SCC is. After reporting on a rare new case of PSCC that was negative for PSCC, this article describes PSCC's clinicopathological features and shows the phenotypic and genotypic differences between PSCC and typical ...
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