Papillary Carcinoma of the Breast Among Omani Women: A Case Series and a Literature Review

Bahaaeldin Baraka,Al Kharusi Suad,Al Farsi Abdulaziz

doi:10.11648/j.jctr.20190703.11

Bahaaeldin Baraka, Al Kharusi Suad + Show 1 more

Open Access

https://doi.org/10.11648/j.jctr.20190703.11

Copy DOI

Abstract

Breast cancer is the most common cause of death from cancer in women worldwide. In 2012, an estimated of 100,000 cases of invasive breast cancer were diagnosed in the United States. The histopathology type is predominantly ductal in about 70–80% of patients followed by invasive lobular carcinoma in 5–15% of case. Invasive papillary carcinomas of the breast are rare, accounting for less than 1-2% of invasive breast cancers. Occasionally the disease is found in men as well. Papillary carcinoma most frequently occurs in older and post-menopausal women. Triple assessment is essential to reach the diagnosis. The typical sonographic appearance of IPC is of hypoechoic area with soft tissue echoes emerging from the wall of the cyst. Invasive micropapillary carcinoma is a luminal-type breast cancer with a propensity for lymphovascular invasion and regional lymph-node metastasis. Intracystic papillary breast cancer (IPC) is best managed in the context of a multidisciplinary team. Surgical excision of the lump with margins in excess of 2 mm is considered satisfactory. Many studies suggest that papillary carcinoma may have a better prognosis than invasive ductal carcinoma (IDC). However, the little available information about papillary carcinoma of the breast underscores the need for further management related studies.

Highlights

According to the World Health Organization (WHO), Invasive papillary carcinoma (IPC) of the breast is a uniquely differentiated adenocarcinoma with a papillary morphology, but otherwise has no clinical, genetic, or prognostic special features [1]
All Invasive papillary carcinomas of the breast patients who were treated at the Royal Hospital from January 2014 to June 2018 were included in the study
This report aimed to shed light on this rare form of breast cancer, and to describe the presentation, management, and outcome of four cases of invasive papillary carcinomas of the breast who presented to our centre with either a palpable mass or discharge from the nipple

Summary

Introduction

According to the World Health Organization (WHO), Invasive papillary carcinoma (IPC) of the breast is a uniquely differentiated adenocarcinoma with a papillary morphology, but otherwise has no clinical, genetic, or prognostic special features [1]. If not, encapsulated papillary carcinoma should be staged as papillary carcinoma in situ [2]. They are characterized by different scales of the finger-like protrusions or leaf-like structure and the presence of arborescent fibrovascular cores covered with myoepithelial cell. Invasive papillary carcinomas of the breast typically present with bloody discharge per nipple, a breast mass, or mammographic abnormalities. There are proliferations of cells arranged around fibrovascular cores, usually grossly forming a mass with a well-defined border and is made up of small, finger-like projections [7]

Objectives

Methods

Findings

Discussion

Conclusion