Abstract
IntroductionOsteoarthritis, a degenerative disorder resulting from the breakdown of articular cartilage, has many possible treatments, but none are disease modifying. Previous studies have shown that OP-1 (also known as BMP-7) is vital to cartilage matrix integrity and repair, stimulates synthesis of cartilage matrix components, proteoglycans and collagen, and has a protective effect against catabolic mediators like MMPs and IL-1. In this study, OP-1 was tested as a novel tissue engineering solution to protect articular cartilage from degeneration during the development of OA as a preventive measure and after four weeks of arthritis progression following an ACL transection as a therapeutic agent for the treatment of OA.
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