Papel de los niveles circulantes del antígeno carbohidrato 125 para identificar al paciente no frágil con IC

Abstract

Introduction and objectivesHeart failure (HF) is an age-related syndrome with a high burden of frailty. However, frailty assessment is not regularly performed in clinical practice. Therefore, a clinical tool for frailty assessment is still required. High levels of Plasma carbohydrate antigen 125 (CA125) are related with a higher risk of adverse clinical events. In this study we aimed to evaluate different CA125 values and its association with frailty categories in HF. MethodsIn this observational, single-center and prospective study, frailty was assessed by Fried score along with the baseline characteristics of the HF stable patient. The discriminative ability of CA125 for predicting frailty status was evaluated by receiver operating characteristic (ROC). ResultsIn 277 patients (74±10 years, 42.59% women, 52.70% left ventricular ejection fraction <50% and 81.22% New York Heart Association grade I-II). There were 61 (22.02%) robust (Fried=0), 95 (34.29%) pre-frail (Fried=1-2) and 121 (46.68%) frail (Fried ≥ 3). CA125 values were lower in robust (13 U/mL (9-23) vs 19 U/mL (12-41), P=.002) and values ≤ 10 U/mL showed a negative predictive value of 66% to rule out the pre-frail/frailty status. Significant, positive, and non-linear association between CA125 and the Fried score (P=.003) was found. CA125 values ≤ 10 U/mL showed a high probability of the presence of robustness. ConclusionsIn a cohort of patients with chronic HF, low values of CA125 (< 10 U/mL) predicted robust patients.