Abstract
The deposition, retention, and clearance of TiO2 particles in normal rats under varying conditions were determined. Assuming that the particle parameters are constant, the deposition can be predicted if the lung weight, concentration of TiO2 in the air, and time of exposure are known. The clearance of particles was followed up to 140 days. The retention half-time after exposure is 14 days for approximately the first 8 days and 88 days thereafter. Experimental emphysema produced by aerosol inhalation and intratracheal injection of papain reduces the clearance rate of TiO2 particles.
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