Abstract
AbstractProcedures have been developed for the preparation of aspartyl containing dipeptides P‐L‐Asp‐AA2 (P=Boc, Cbz and Moz; AA2=Phe‐R or Ala‐R; R=OH, OBzl and OTMB) using papain as a catalyst. The pH dependent of esterase activity by papain catalyzed hydrolysis have been studied. The papain catalyzing reaction can be reacted in aqueous solution, buffer solution or cosolvent system in a thermodynamically controlled approach. A procedure for the conversion of the artificial sweetner precursor P‐Asp‐Phe‐OH to the aspartame is studied also.
Published Version
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