Abstract
A 41-year-old man with a history of poorly controlled HIV/AIDS and persistent Kaposi sarcoma (KS) despite paclitaxel treatment was admitted with jaundice. Laboratory studies revealed cholestatic liver enzymes with CA19-9 elevation. Positron emission tomography/computed tomography scan showed diffuse enhancement of the pancreas (Figure A). Endoscopic ultrasound demonstrated a panpancreatic infiltration with marked vascularity on Doppler analysis (Figure B) and biliary obstruction. Histopathology of endoscopic ultrasound–guided aspiration was diagnostic of panpancreatic KS revealing spindle/epithelioid cells separated by slitlike vascular spaces (Figure C) staining positive for CD31 and human herpesvirus-8.
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